pentobarbital will decrease the extent or outcome of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will decrease the extent or influence of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Induction of microsomal enzymes by this drug, might shorten the fifty percent-lifetime of doxycycline for so long as two months immediately after barbiturate therapy discontinued; observe scientific response to doxycycline carefully if both drugs administered concurrently
pentobarbital will lessen the extent or effect of irinotecan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will reduce the extent or result of darifenacin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will lower the extent or result of conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will lower the level or outcome of temsirolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lower the extent or impact of finasteride by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.
Soon after stopping a CYP3A4 inducer, as the effects from the inducer decline, the fentanyl plasma focus will boost which could increase or lengthen both the therapeutic and adverse effects.
Remark: Barbiturates may well raise adverse effects, together with respiratory despair, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs.
pentobarbital increases toxicity of buprenorphine, lengthy-acting injection by check here pharmacodynamic synergism. Modify Therapy/Watch Intently. Coadministration of buprenorphine and benzodiazepines or other CNS depressants raises chance of adverse reactions together with overdose, respiratory depression, and Loss of life. Cessation of benzodiazepines or other CNS depressants is preferred normally.
pentobarbital will reduce the level or outcome of triamcinolone acetonide injectable suspension by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
To minimize the possibility of overdosage or the development of dependence, Restrict the prescribing and dispensing of sedative-hypnotic barbiturates, to the amount needed for your interval till the following appointment
pentobarbital will minimize the extent or influence of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.